Objective(s): Since bisphenol A (BPA) induces bone loss and phytoestrogens enhance the osteoblastogenesis by binding to the non-classical and classical oestrogen receptors, respectively, the present study was aimed to observe the osteoprotective effect of phytoestrogens on BPA-induced osteoblasts in hFOB 1.19 cells.Materials and Methods:...

The majority of breast cancers are oestrogen dependent and in postmenopausal women the supply of oestrogens in breast tissue is derived from the peripheral conversion of circulating androgens. There is, however, a paradox concerning the epidemiology of breast cancer and the dietary intake of phytoestrogens that bind weakly to oestrogen receptors and initiate oestrogen-dependent transcription. I...

Phytoestrogens are polyphenol, non-steroidal substances of plant origin, resembling 17β-estradiol in structure. These substances can act as either agonists or antagonists of oestrogen receptors α and β. Phytoestrogens are widely used to alleviate menopausal symptoms, such as hot flushes and night sweats. Most of the currently available products of plant origin registered to soften climacteric s...

The concentrations of seventeen endocrine disruptor compounds (EDCs) that included oestrogens, phytoestrogens, sitosterol, and banned industrial pollutants were investigated at ten sites the Douro River estuary. Surface waters collected during 2019. After evaluating physicochemical data (ammonia, nitrates, nitrites phosphates), filtrated submitted to solid-phase extraction (SPE) extract pre-con...

Steroids and related compounds are important in disease development and prevention, via steroid receptor-mediated and receptor-independent mechanisms. Interaction of endogenous oestrogens with the oestrogen receptor has unfortunate mitogenic effects in breast cancer. However, dietary consumption of non-steroidal weak oestrogens, such as the soy isoflavone phytoestrogens genistein and diadzein, ...

: Phytoestrogens are estrogen analogues of plant origin, allowing them to act as agonists at receptors.

Gap junctional channels between cells provide a pathway for exchange of regulatory ions and small molecules. We previously demonstrated that expression of connexins and cell-to-cell communication parallel osteoblastic differentiation and that nonspecific pharmacological inhibitors of gap junctional communication inhibit alkaline phosphatase activity. In this study, we stably transfected connexi...

Prostate cancer frequently metastasizes to the skeleton, producing painful osteoblastic lesions, which are associated with significant morbidity and mortality. This bone tropism involves the bidirectional paracrine interactions between prostate cancer cells and osteoblasts. These interactions enhance prostate cancer cell survival and proliferation of osteoblasts. Therefore, agents that can indu...

It is well established that soybean products contain the phytoestrogens daidzein and genistein. 1-3 We have measured the levels of these compounds in several soy-based infant formulas available in New Zealand. The quantities recommended by manufacturers for infant feeding provide an intake (per kg body weight) of approximately three to five times as much daidzein and genistein than amounts whic...

Phytoestrogens are naturally occurring phytochemicals found in plants and plant products. These is structurally and functionally similar to 17b oestradiol or synthetic oestrogens. (Burton and Wells, 2002) Even a low dose phytoestrogen diet can induce developmental and maturational abnormalities in both laboratory animals and domestic livestock and can affect human health too. (Fredrick et al., ...